Modafinil is a drug which falls in the class ‘Analeptic’. An analeptic is defined as a drug which is used as a stimulant to the central nervous system. This drug is used to treat diseases such as narcolepsy, inordinate hours of sleep etc. This drug is responsible for increasing the amount of monoamines discharged from the synaptic terminals. These monoamines mainly include catecholamines norepinephrine and dopamine. This medicine is also responsible for increasing the concentration of hypothalamic histamine. As it increases the levels of histamine in the hypothalamus, it is used to keep a person awake. In other words, this drug can be used as a wakefulness agent.
Many people all over the globe suffer from narcolepsy which is a kind of sleeping disorder which is characterized by sudden and uncontrollable episodes of deep sleep. This drug is used to treat people suffering from narcolepsy and other disorders related to sleep such as obstructive sleep apnea/ hypopnea which are characterized by transient cessation of respiration, shift work sleep disorder etc. The doctors should pay attention to the cause of excessive sleepiness in the patient. At times it may be caused due to the presence of several sleeping disorders in the patient. The patients suffering from narcolepsy and other severe sleeping disorders are subjected to long term treatment using the drug Modafinil.
Each tablet of Modafinil 200 mg consists of Modafinil and various other inactive ingredients such as lactose, micro crystalline cellulose, pregelatinized starch, croscarmellose sodium, povidone and magnesium stearate.
Though it is known that Modafinil is used as a wakefulness agent, the actual process which this drug uses to keep a person awake is not known. The effects of dosing a patient with this drug are similar to the effects of dosing a person with agents which are related to epinephrine such as amphetamine and methylphenidate. However, the properties of Modafinil vary from those of agents related to epinephrine. This medicine is not capable of inhibiting the action of phosphodiesterases. The wakefulness which is influenced by the dosage of Modafinil can be suppressed by the use of alpha adrenergic receptor antagonist prazosin. Other than acting as a wakefulness agent, this drug is also capable of producing euphoric and psychoactive effects.
Modafinil is capable of reducing the sleepiness in an individual. However, it doesn’t guarantee full freedom from the temptation to sleep. This drug can be easily misused by various individuals and hence, this drug falls in the category of federally controlled substances. The patients are not supposed to distribute this drug with the other patients who suffer from similar kind of problems because this drug might prove to be fatal for them. This drug alters the concentration of different chemicals which exist in the brain and are responsible for controlling the sleep and wake cycle in an individual in order to keep a person awake.